[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"content-doc-dcio6c0f77cb":3},{"user":4,"document":8,"mainDocument":27,"columnUrl":29,"subscription":30,"footer":42,"text":80},{"isAuthenticated":5,"isAdmin":5,"displayName":6,"avatarUrl":6,"nid":6,"groupLevel":7},false,"",-10,{"id":9,"fullTitle":10,"subTitle":6,"url":11,"columnId":12,"columnName":13,"columnUrl":14,"summary":6,"contentHtml":15,"mainContentHtml":6,"posterUrl":16,"createDate":17,"displayDate":18,"displayDateSlash":19,"pageviews":20,"tags":21,"hidden":5,"isSubContent":5,"replyDocOrTargetId":6,"contentType":23,"videoId":6,"liveVideoUrl":6,"useContentVideo":5,"duration":24,"price":24,"priceText":25,"priceBadgeText":25,"priceBadgeClass":26,"freeForMinGroupLevel":24,"redirectUrl":6,"readyToStream":5},"dcio6c0f77cb","mRNA癌症疫苗里程碑！Moderna(MRNA)联手默沙东(MRK)黑色素瘤试验成功，盘前股价飙涨80%","\u002Fdoc\u002Fdcio6c0f77cb","col18178739ee","美股资讯","\u002Fcol\u002Fcol18178739ee","\u003Cp> \u003C\u002Fp>\n\u003Cp>\u003Cspan>美股投资网获悉，Moderna Inc.(MRNA)与默沙东(MRK)宣布，其个性化癌症疫苗在一项大规模后期试验中成功降低黑色素瘤复发风险，标志着基于mRNA技术的癌症疗法取得重要里程碑。该项试验达到了主要终点——数据显示，该疫苗与默沙东免疫药物Keytruda联用，相较于单独使用Keytruda，能够降低黑色素瘤的复发率。两家公司在周三的声明中表示，该研究同时达到了关键次要终点，即证明该疫苗有助于防止肿瘤向身体其他部位扩散。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>两家公司表示，这是任何基于mRNA的癌症疗法首次取得积极的后期试验结果。受此消息提振，Moderna股价在纽约盘前交易中一度飙升逾100%。截至发稿，盘前大涨80%，默沙东股价上涨约7.2%。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>有关该疫苗在无复发生存期(即患者癌症未复发的时间长度)方面具体改善幅度的详细数据尚未公布。该试验仍在继续，以评估接种疫苗的患者是否能够获得更长的总生存期。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>黑色素瘤是最严重的皮肤癌类型。据美国癌症协会统计，美国每年约有11.2万人被确诊，约8,500人因此死亡。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>两家公司在声明中表示，将讨论向监管机构提交上市申请的事宜，并在即将召开的医学会议上公布相关数据。Moderna首席执行官斯特凡纳·邦塞尔在接受采访时表示，根据监管审评结果，该产品最快有望于2027年获批上市。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>邦塞尔表示“这是mRNA科学的一个非凡里程碑。”\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>两家公司合作开发该疫苗(名为intismeran autogene)的底层科学已逾十年。该疫苗采用与Moderna新冠疫苗相同的信使RNA技术，并根据患者的具体肿瘤突变进行个性化定制。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>在试验中，患者在接受肿瘤手术切除后，给予mRNA疫苗联合默沙东Keytruda治疗。研究中的对照组患者仅接受Keytruda单药治疗——这是用于高风险患者预防复发的标准治疗方案。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>其目标是让两种药物协同作用，训练人体免疫系统攻击任何残留的癌细胞。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>得益于该癌症疫苗的前景，Moderna股价从年初至周二收盘已累计上涨113%。黑色素瘤试验被视为检验该方法有效性的关键早期测试。默沙东与Moderna正在其他癌种(包括肺癌)中开展测试，但黑色素瘤相关研究进展最为领先。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>科学家们长期以来一直追求疫苗能使人体自身防御系统对抗癌症、教会免疫系统识别肿瘤的分子指纹并摧毁残留细胞的想法。然而，直到现在，让这类疫苗发挥作用一直极为困难。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>默沙东肿瘤早期开发负责人简·希利在数据公布前数周接受采访时表示“治疗性疫苗一直是癌症领域的‘圣杯’。人们以各种方式尝试这项工作已超过百年。”她指出，此类疫苗的潜在优势之一是在不显著增加副作用的前提下延长生存期。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>两家公司今年早些时候曾表示，在一项中期试验中，接受mRNA疫苗联合Keytruda治疗的皮肤癌患者，五年后死亡或癌症复发的风险较仅接受Keytruda治疗的患者低49%。\u003C\u002Fspan>\u003C\u002Fp>\n\u003Cp>\u003Cspan>最专业的美股资讯,推荐美股大数据 \u003Ca 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buy@TradesMax.com 美国电话 626-378-3637","公司介绍","\u003Cp class=\"MsoNormal\">美股大数据 \u003Ca href=\"https:\u002F\u002Fstockwe.com\" rel=\"noopener\">StockWe.com\u003C\u002Fa> 是一个美国领先的金融和美股信息大数据提供商，紧盯华尔街金融市场和行情，2008年成立于美国硅谷，创始人是前纽约证券交易所资深分析师Ken，联合多位摩根斯坦利分析师，谷歌 Meta工程师利用AI和大数据，配合十多年美股实战经验和业内量化交易模型，每天处理海量股票数据：挖掘潜力大牛股，捕捉期权异动大单，实时主力资金流向、机构持仓变化、川普突发新闻，美股买卖信号第一时间发到您手机APP。\u003C\u002Fp>","专业美股投资者都在这里",{"loading":81,"search":82,"searchPlaceholder":82,"hotContent":83,"draft":84,"noData":85,"searchNoData":86,"courseContent":87,"more":88,"buyNow":89,"subscribeNow":90,"encoding":91,"paidContent":92},"Loading...","搜索","热门内容","草稿","目前没有任何内容公布","当前检索内容没有数据","课程内容","更多","立即购买后观看","- 立即订阅 -","视频编码中...","付费内容"]